Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U.Leuven, Leuven, Belgium.
Tissue Eng Part A. 2010 Nov;16(11):3353-61. doi: 10.1089/ten.TEA.2010.0130. Epub 2010 Jul 27.
Despite a myriad of studies confirming the interaction between biology and mechanics, the exact nature of the main mechanical stimuli and their influence on the bone regeneration processes are still unclear. The hypothesis of this study was that the outcome of peri-implant healing under different implant loading regimens can be explained by the influence of fluid flow on the combination of angiogenesis and osteogenesis through its influence on cell proliferation and differentiation. To investigate this hypothesis a mathematical model of bone regeneration was applied to simulate the peri-implant healing in an in vivo repeated sampling bone chamber for different axial micromechanical implant loading regimes. When mechanical loading was modeled to influence both osteogenic and angiogenic processes, a good agreement was observed between simulations and experiments concerning the amount of bone in the bone chamber, its radial and longitudinal distribution, and the bone-implant contact for different implant displacement magnitudes.
尽管有大量研究证实了生物学和力学之间的相互作用，但主要机械刺激的确切性质及其对骨再生过程的影响仍不清楚。本研究的假设是，不同种植体加载方案下的种植体周围愈合结果可以通过流体流动对血管生成和成骨的结合的影响来解释，这种影响是通过对细胞增殖和分化的影响实现的。为了验证这一假设，应用了一个骨再生的数学模型来模拟不同轴向微力学种植体加载方案下体内重复取样骨室中的种植体周围愈合情况。当机械加载被建模为影响成骨和血管生成过程时，对于不同种植体位移幅度的骨室中骨量、其径向和纵向分布以及骨-种植体接触，模拟和实验之间观察到了很好的一致性。
