Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
BMC Biol. 2010 May 19;8:59. doi: 10.1186/1741-7007-8-59.
Important advances in the field of tissue engineering are arising from increased interest in novel biomaterial designs with bioactive components that directly influence cell behavior. Following the recent work of Mitchell and co-workers published in BMC Biology, we review how spatial and temporal control of signaling molecules in a matrix material regulates cellular responses for tissue-specific applications.
组织工程领域的重要进展源于对具有生物活性成分的新型生物材料设计的浓厚兴趣，这些成分直接影响细胞行为。继 Mitchell 及其同事最近在 BMC 生物学杂志上发表的工作之后，我们回顾了基质材料中信号分子的时空控制如何调节细胞对特定于组织的应用的反应。
