Department for Innovation and Quality. Institute for Decentralized Public Health Services, INDESALUD, Campeche State, Mexico.
BMC Public Health. 2010 Jun 7;10:318. doi: 10.1186/1471-2458-10-318.
Insulin resistance is the primary metabolic disorder associated with obesity; yet little is known about its role as a determinant of the metabolic syndrome in obese children. The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents.
An analytical, cross-sectional and population-based study was performed in forty-four public primary schools in Campeche City, Mexico. A total of 466 obese children and adolescents between 11-13 years of age were recruited. Fasting glucose and insulin concentrations, high density lipoprotein cholesterol, triglycerides, waist circumference, systolic and diastolic blood pressures were measured; insulin resistance and metabolic syndrome were also evaluated.
Out of the total population studied, 69% presented low values of high density lipoprotein cholesterol, 49% suffered from abdominal obesity, 29% had hypertriglyceridemia, 8% presented high systolic and 13% high diastolic blood pressure, 4% showed impaired fasting glucose, 51% presented insulin resistance and 20% metabolic syndrome. In spite of being obese, 13% of the investigated population did not present any metabolic disorder. For each one of the components of the metabolic syndrome, when insulin resistance increased so did odds ratios as cardiometabolic risk factors.
Regardless of age and gender an increased degree of insulin resistance is associated with a higher prevalence of disorders in each of the components of the metabolic syndrome and with a heightened risk of suffering metabolic syndrome among obese children and adolescents.
胰岛素抵抗是与肥胖相关的主要代谢紊乱；然而，其作为肥胖儿童代谢综合征决定因素的作用知之甚少。本研究旨在评估肥胖儿童和青少年中胰岛素抵抗程度与代谢综合征各组分之间的相关性。
在墨西哥坎佩切市的 44 所公立小学进行了一项分析性、横断面和基于人群的研究。共招募了 466 名 11-13 岁的肥胖儿童和青少年。测量了空腹血糖和胰岛素浓度、高密度脂蛋白胆固醇、甘油三酯、腰围、收缩压和舒张压；还评估了胰岛素抵抗和代谢综合征。
在所研究的总人口中，69%的人高密度脂蛋白胆固醇值较低，49%的人患有腹型肥胖，29%的人存在高甘油三酯血症，8%的人收缩压升高，13%的人舒张压升高，4%的人空腹血糖受损，51%的人胰岛素抵抗，20%的人代谢综合征。尽管肥胖，仍有 13%的研究人群没有任何代谢紊乱。对于代谢综合征的每一个组成部分，随着胰岛素抵抗的增加，作为心血管代谢危险因素的比值比也随之增加。
无论年龄和性别如何，胰岛素抵抗程度的增加与代谢综合征各组成部分的紊乱患病率增加以及肥胖儿童和青少年代谢综合征风险增加相关。
