血浆肿瘤坏死因子-α、白细胞介素-6 与美洲印第安妇女体重增加的不相关关系：自然体重变化和糖耐量受损的长期前瞻性研究。
Disassociated relation between plasma tumor necrosis factor-alpha, interleukin-6 and increased body weight in Amerindian women: A long-term prospective study of natural body weight variation and impaired glucose tolerance.
机构信息
Vascular Center, Lund University, Skåne University Hospital, S-205 02 Malmö, Sweden.
出版信息
Diabetol Metab Syndr. 2010 Jun 8;2:38. doi: 10.1186/1758-5996-2-38.
BACKGROUND
Inflammatory cytokines are linked to obesity-related insulin resistance and may predict type 2 diabetes independently of obesity. We previously reported that a majority of a cohort of 73 non-diabetic women with normal plasma (p-)glucose with Amerindian heritage in Lima, Peru, during a 5-year period increased both body weight and p-glucose levels, yet p-insulin was unaltered. A high proportion of palmitoleic acid (16:1n-7) in serum (s) and systolic blood pressure (SBP) were independent predictors of high p-glucose. Whether cytokines also contributed is, however, not known.
METHODS
During 5 years we prospectively investigated the relation between changed concentrations of p-tumor necrosis factor (TNF)-alpha, p-interleukin (IL)-6 and circulating insulin and glucose in relation to the natural variation of body weight. Study variables included anthropometric measurements, p-insulin, TNF-alpha, IL-6, SBP and the proportion of 16:1n-7 in s-fatty acid composition.
RESULTS
Weight and waist differences correlated negatively to the difference in p-TNF-alpha but positively to differences in p-IL-6 and p-insulin, whereas the increase of p-glucose from baseline to follow-up did not correlate with changes in levels of the two cytokines. In multiple regression analysis changes of TNF-alpha and insulin contributed independently to the variance in weight. P-insulin at baseline and weight change were determinants of fasting p-insulin at follow-up. Multiple regression analysis revealed that weight change (t-value = - 2.42; P = 0.018) and waist change (t-value = 2.41; P = 0.019) together with S-16:1n-7 (p < 0.0001) and SBP (p = 0.0005) at baseline were significant predictors of p-glucose at follow-up.
CONCLUSION
Our prospective study of Amerindian women revealed disassociations between changes in p-TNF-alpha and p-IL-6 in relation to variation in body weight. A high proportion of s-16:1n-7, SBP at baseline together with weight and waist changes were independent predictors of p-glucose at follow-up. The exact role of the opposite effects and clinical impact of p-TNF-alpha and p-IL-6 on loss and gain of body weight and indirectly on the development of glucose intolerance is not known.
背景
炎症细胞因子与肥胖相关的胰岛素抵抗有关，并且可能独立于肥胖预测 2 型糖尿病。我们之前报告说，在秘鲁利马，73 名具有美洲印第安人血统的非糖尿病女性在 5 年内，大多数人的血浆（p-）葡萄糖正常，体重和 p-葡萄糖水平均升高，但 p-胰岛素不变。血清（s）中棕榈油酸（16:1n-7）和收缩压（SBP）的比例较高是 p-葡萄糖升高的独立预测因子。然而，细胞因子是否也有贡献尚不清楚。
方法
在 5 年内，我们前瞻性地研究了体重变化与 p-肿瘤坏死因子（TNF）-α、p-白细胞介素（IL）-6 和循环胰岛素之间浓度变化的关系。研究变量包括人体测量学测量、p-胰岛素、TNF-α、IL-6、SBP 和 s-脂肪酸组成中 16:1n-7 的比例。
结果
体重和腰围的差异与 p-TNF-α的差异呈负相关，但与 p-IL-6 和 p-胰岛素的差异呈正相关，而从基线到随访时 p-葡萄糖的增加与两种细胞因子水平的变化无关。多元回归分析显示，TNF-α和胰岛素的变化独立于体重的变化。基线时的 p-胰岛素和体重变化是随访时空腹 p-胰岛素的决定因素。多元回归分析显示，体重变化（t 值=-2.42；P=0.018）和腰围变化（t 值=2.41；P=0.019）与基线时的 S-16:1n-7（p<0.0001）和 SBP（p=0.0005）一起是随访时 p-葡萄糖的显著预测因子。
结论
我们对美洲印第安妇女的前瞻性研究显示，p-TNF-α和 p-IL-6 的变化与体重变化之间存在不一致。基线时 s-16:1n-7、SBP 以及体重和腰围的变化与随访时 p-葡萄糖的变化独立相关。p-TNF-α和 p-IL-6 对体重增减的相反作用及其对葡萄糖耐量异常发展的临床影响的确切作用尚不清楚。
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