Scimeca Christy L, Bharara Manish, Fisher Timothy K, Giovinco Nicholas, Armstrong David G
Southern Arizona Limb Salvage Alliance, Department of Surgery, University of Arizona College of Medicine, Tucson, USA.
Foot Ankle Spec. 2010 Aug;3(4):190-3. doi: 10.1177/1938640010371121. Epub 2010 Jun 8.
Negative-pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. The authors present a description of real-time streaming therapy of a variety of wound chemotherapeutic agents through NPWT. Doxycycline, which acts as a competitive inhibitor of matrix metalloproteinases and tumor necrosis factor alpha and further decreases inflammation through the reduction of nitrous oxide production, may prove helpful when delivered in this manner. To the authors' knowledge, this is the first report in the literature describing this method of delivery of doxycycline.
负压伤口治疗（NPWT）常用于复杂伤口的治疗。作者介绍了通过NPWT实时输注多种伤口化疗药物的情况。强力霉素作为基质金属蛋白酶和肿瘤坏死因子α的竞争性抑制剂，并通过减少一氧化氮的产生进一步减轻炎症，以这种方式给药可能会有帮助。据作者所知，这是文献中首次描述这种强力霉素给药方法的报告。
