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胰岛素在持续滴注负压伤口治疗中作为“伤口化疗”的新用途。

Novel use of insulin in continuous-instillation negative pressure wound therapy as "wound chemotherapy".

作者信息

Scimeca Christy L, Bharara Manish, Fisher Timothy K, Kimbriel Heather, Mills Joseph L, Armstrong David G

机构信息

Southern Arizona Limb Salvage Alliance (SALSA), College of Medicine, University of Arizona, Tucson, Arizona 85724, USA.

出版信息

J Diabetes Sci Technol. 2010 Jul 1;4(4):820-4. doi: 10.1177/193229681000400408.

DOI:10.1177/193229681000400408
PMID:20663443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2909511/
Abstract

Negative pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. A variety of wound chemotherapeutic agents such as insulin, which acts as a growth factor, may prove helpful in treatment as well. We present a case report in which insulin was used as a chemotherapeutic agent in continuous-instillation NPWT. To our knowledge, this is the first report in the literature describing this method of delivery.

摘要

负压伤口治疗(NPWT)常用于复杂伤口的治疗。多种伤口化疗药物,如起生长因子作用的胰岛素,可能在治疗中也有帮助。我们报告一例将胰岛素用作持续滴注NPWT化疗药物的病例。据我们所知,这是文献中描述这种给药方法的首例报告。

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本文引用的文献

1
Wound chemotherapy by the use of negative pressure wound therapy and infusion.采用负压伤口治疗和灌注进行伤口化疗。
Eplasty. 2010 Jan 8;10:e9.
2
Phenytoin enhances collagenization in excision wounds and tensile strength in incision wounds.苯妥英可增强切除伤口的胶原化以及切口伤口的抗张强度。
Pharmazie. 2009 Sep;64(9):584-6.
3
Evaluation of toxic side effects of clinically used skin antiseptics in vitro.评价临床使用的皮肤消毒剂的体外毒副作用。
J Surg Res. 2010 Dec;164(2):344-50. doi: 10.1016/j.jss.2009.04.029. Epub 2009 May 18.
4
A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing.一项随机、双盲、安慰剂对照试验,以确定局部应用胰岛素对伤口愈合的影响。
Ostomy Wound Manage. 2009 Aug 1;55(8):22-8.
5
IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.
Biochem Soc Trans. 2009 Aug;37(Pt 4):882-5. doi: 10.1042/BST0370882.
6
The impact of topical phenytoin on recalcitrant neuropathic diabetic foot ulceration.局部应用苯妥英对顽固性糖尿病神经病变性足部溃疡的影响。
J Wound Care. 2009 Jan;18(1):33-7. doi: 10.12968/jowc.2009.18.1.32146.
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Biofilms in wounds: management strategies.伤口中的生物膜:管理策略
J Wound Care. 2008 Nov;17(11):502-8. doi: 10.12968/jowc.2008.17.11.31479.
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Biofilms and chronic wound inflammation.生物膜与慢性伤口炎症。
J Wound Care. 2008 Aug;17(8):333-41. doi: 10.12968/jowc.2008.17.8.30796.
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Int Wound J. 2008 Jun;5(3):376-87. doi: 10.1111/j.1742-481X.2007.00405.x.
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