Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA.
Mol Syst Biol. 2010 Jun 8;6:377. doi: 10.1038/msb.2010.31.
Assembly of a transcriptional and post-translational molecular interaction network in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre-replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues.
B 细胞中转录和翻译后分子相互作用网络的组装，即人类 B 细胞相互作用组（HBCI），揭示了一个分层的转录控制模块，其中 MYB 和 FOXM1 作为生发中心（GC）增殖的协同主调控因子发挥作用。80%由这些转录因子共同调控的基因在 GC 中被激活，包括编码参与调节 DNA 预复制、复制和有丝分裂的蛋白质的基因。这些结果表明，HBCI 分析可用于鉴定主要人类细胞表型的决定因素，并为正常和病理组织提供了一种普遍适用的范例。
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