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肌醇需求蛋白 1/X 盒结合蛋白 1 是一个调节枢纽，将内质网稳态与先天免疫和代谢联系起来。

Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism.

机构信息

Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI, USA.

出版信息

EMBO Mol Med. 2010 Jun;2(6):189-92. doi: 10.1002/emmm.201000076.

DOI:10.1002/emmm.201000076
PMID:20533428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3042734/
Abstract

Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses.

摘要

肌醇需求酶 1（IRE1）/X 盒结合蛋白 1（XBP1）介导的信号转导代表了未折叠蛋白反应中最保守的分支。最近的一系列研究揭示了该途径在协调代谢和免疫反应中的新的、可能是古老的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a82/3377321/2e184be4a2bf/emmm0002-0189-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a82/3377321/2e184be4a2bf/emmm0002-0189-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a82/3377321/2e184be4a2bf/emmm0002-0189-f1.jpg

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Nat Med. 2010 Apr;16(4):429-37. doi: 10.1038/nm.2099. Epub 2010 Mar 28.
3
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Front Immunol. 2022 Jan 3;12:801724. doi: 10.3389/fimmu.2021.801724. eCollection 2021.
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