Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland.
Int J Dermatol. 2010 May;49(5):492-9. doi: 10.1111/j.1365-4632.2010.04355.x.
A thorough examination of the skin is essential for accurate disease diagnostics, evaluation of the effectiveness of topically applied drugs and the assessment of the results of dermatologic surgeries such as skin grafts. Knowledge of skin parameters is also important in the cosmetics industry, where the effects of skin care products are evaluated. Due to significant progress in the electronics and computer industries, sophisticated analytic devices are increasingly available for day-to-day diagnostics. The aim of this article is to review several advanced methods for in vivo skin analysis in humans: magnetic resonance imaging, electron paramagnetic resonance, laser Doppler flowmetry and time domain reflectometry. The molecular bases of these techniques are presented, and several interesting applications in the field are discussed. Methods for in vivo assessment of the biomechanical properties of human skin are also reviewed.
对皮肤进行全面检查对于准确诊断疾病、评估局部应用药物的效果以及评估皮肤移植等皮肤科手术的结果至关重要。在化妆品行业中，了解皮肤参数也很重要，因为可以评估护肤品的效果。由于电子和计算机行业的显著进步，越来越多的复杂分析设备可用于日常诊断。本文旨在综述几种用于人体皮肤无创分析的先进方法：磁共振成像、电子顺磁共振、激光多普勒血流计和时域反射计。介绍了这些技术的分子基础，并讨论了该领域的一些有趣应用。还综述了用于评估人体皮肤生物力学特性的体内评估方法。
