Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
Int J Dermatol. 2010 May;49(5):517-9. doi: 10.1111/j.1365-4632.2010.04309.x.
Patch testing is performed to evaluate suspected allergic contact dermatitis. Common wisdom suggests that various allergens cross-react but only a few larger studies have published confirmations of this. The purpose of our study was to identify significant correlations between positive test reactions in a screening series.
A total of 1235 patients undergoing patch testing to the Hermal standard series at the Massachusetts General Hospital, Contact Dermatitis Clinic between 1990 and 2006 were investigated.
Two or more positive reactions were seen in 411 patients (33.3%). Sensitizations to eight pairs of allergens were found to have significant correlation (P <or= 0.0001). A strong association was observed for cross reactions between formaldehyde and its releasers quaternium 15 and imidazolidinyl urea and between balsam of Peru and fragrance mix. Moreover, significant co-sensitization was identified for potassium dichromate and colophony. Three significant pairings in our study were associations between fragrances and metals. Our data confirm the previously published cross-reactions in the literature between fragrance components, and formaldehyde and formaldehyde-releasing preservatives. The increased numbers of patients with metal and fragrance sensitization can be considered as a random finding due to independent sensitization.
Being aware of cross-reacting allergens is essential to success in resolving allergic dermatitis when counseling patients.
斑贴试验用于评估疑似过敏性接触性皮炎。一般认为，各种过敏原存在交叉反应，但仅有少数较大的研究发表了对此的证实。我们研究的目的是确定筛选系列中阳性测试反应之间的显著相关性。
在 1990 年至 2006 年间，我们对在马萨诸塞州总医院接触性皮炎诊所进行 Hermal 标准系列斑贴试验的 1235 名患者进行了调查。
411 名患者（33.3%）出现了 2 个或更多阳性反应。发现对 8 对过敏原的致敏作用具有显著相关性（P≤0.0001）。在甲醛与其释放剂季铵盐 15 和咪唑烷基脲之间以及秘鲁香脂和香料混合物之间观察到强烈的交叉反应，而且在重铬酸钾和松香之间也存在显著的共同致敏作用。在我们的研究中，有 3 对有意义的配对是香料和金属之间的关联。我们的数据证实了文献中先前发表的香料成分之间、甲醛和甲醛释放防腐剂之间的交叉反应。由于独立致敏作用，金属和香料致敏患者数量的增加可以被认为是随机发现。
在为患者提供咨询时，了解交叉反应性过敏原对于成功解决过敏性皮炎至关重要。
