Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Dermatitis. 2013 Mar-Apr;24(2):64-72. doi: 10.1097/DER.0b013e318284da33.
Allergic contact dermatitis (ACD) of the vulva arises as a primary condition or develops secondary to topical agents. We aimed to describe the incidence of ACD in patients presenting with vulvar symptoms and to identify the allergens of most importance.
Using a database of the patch testing results from 3 geographically distinct sites, we identified patients tested to a gynecologic series between 2003 and 2010. Patients had patch testing to the standard European battery and a gynecologic series. Patch testing was in line with accepted universal methods: application on day 1, allergen removal and initial reading on day 3, and final reading on day 5.
Ninety patients were included. Thirty-five (39%) had a relevant positive result. The 5 allergens with the highest number of cases with a relevant reaction were natural fragrance mix 2%, balsam of Peru, benzocaine 5%, fragrance mix 8%, and quaternium 15 1%. The most common gynecologic series allergen to cause a relevant reaction was terconazole.
Allergic contact dermatitis is a frequent finding in patients presenting with vulvar symptoms. We identified a relevant positive result to patch testing in 39%. We found fragrances, medicaments, and preservatives to be of most relevance.
外阴过敏性接触性皮炎（ACD）可原发于外阴，也可由局部接触物引起。我们旨在描述外阴症状患者中 ACD 的发生率，并确定最重要的过敏原。
利用来自 3 个地理位置不同的点的斑贴试验结果数据库，我们确定了在 2003 年至 2010 年间接受妇科系列斑贴试验的患者。患者接受标准欧洲电池和妇科系列斑贴试验。斑贴试验符合公认的通用方法：第 1 天贴敷，第 3 天去除过敏原并进行初步读取，第 5 天进行最终读取。
共纳入 90 例患者。35 例（39%）有相关阳性结果。与反应相关的病例数最多的 5 种过敏原分别为天然香料混合物 2%、秘鲁香脂、苯佐卡因 5%、香料混合物 8%和季铵盐 15 1%。引起相关反应的最常见妇科系列过敏原是特康唑。
外阴症状患者中过敏性接触性皮炎很常见。我们发现 39%的患者斑贴试验阳性。我们发现香料、药物和防腐剂是最相关的过敏原。
