Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
Mol Oncol. 2010 Jun;4(3):230-41. doi: 10.1016/j.molonc.2010.04.009. Epub 2010 Apr 28.
Micro-RNAs (miRs) are a recently described class of genes, encoding small non-coding RNA molecules, which primarily act by down-regulating the translation of target mRNAs. miRs are involved in a range of normal physiological processes, notably differentiation and cell type determination. It has become apparent that they are also key factors in cancer, playing both oncogenic and tumour-suppressing roles. We discuss here what is known of miR biology in the normal breast, and of their emerging roles in breast cancer.
微小 RNA（miRs）是最近描述的一类基因，编码小的非编码 RNA 分子，主要通过下调靶 mRNA 的翻译来发挥作用。miRs 参与了一系列正常的生理过程，特别是分化和细胞类型决定。显然，它们也是癌症的关键因素，发挥着致癌和抑癌的作用。我们在这里讨论了 miR 在正常乳腺中的生物学特性，以及它们在乳腺癌中的新兴作用。
