微小 RNA 与乳腺癌。
Micro-RNAs and breast cancer.
机构信息
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
出版信息
Mol Oncol. 2010 Jun;4(3):230-41. doi: 10.1016/j.molonc.2010.04.009. Epub 2010 Apr 28.
Abstract
Micro-RNAs (miRs) are a recently described class of genes, encoding small non-coding RNA molecules, which primarily act by down-regulating the translation of target mRNAs. miRs are involved in a range of normal physiological processes, notably differentiation and cell type determination. It has become apparent that they are also key factors in cancer, playing both oncogenic and tumour-suppressing roles. We discuss here what is known of miR biology in the normal breast, and of their emerging roles in breast cancer.
摘要
微小 RNA（miRs）是最近描述的一类基因，编码小的非编码 RNA 分子，主要通过下调靶 mRNA 的翻译来发挥作用。miRs 参与了一系列正常的生理过程，特别是分化和细胞类型决定。显然，它们也是癌症的关键因素，发挥着致癌和抑癌的作用。我们在这里讨论了 miR 在正常乳腺中的生物学特性，以及它们在乳腺癌中的新兴作用。
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