Department of Surgery, University College Medical School, University of London, London, England, UK.
Endocrinol Metab Clin North Am. 2010 Mar;39(1):169-81, xi. doi: 10.1016/j.ecl.2009.11.001.
This article discusses the inevitable use of growth factors for enhancing muscle strength and athletic performance. Much effort has been expended on developing a treatment of muscle wasting associated with a range of diseases and aging. Frailty in the aging population is a major socioeconomic and medical problem. Emerging molecular techniques have made it possible to gain a better understanding of the growth factor genes and how they are activated by physical activity. The ways that misuse of growth factors may be detected and verified in athletes and future challenges for detecting manipulation of signaling pathways are discussed.
本文讨论了生长因子在增强肌肉力量和运动表现方面的必然应用。人们付出了大量努力来开发一种治疗与多种疾病和衰老相关的肌肉减少症的方法。老年人的虚弱是一个主要的社会经济和医疗问题。新兴的分子技术使人们能够更好地了解生长因子基因以及它们如何被身体活动激活。讨论了在运动员中检测和验证生长因子滥用的方法，以及检测信号通路操纵的未来挑战。
