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[长期持续全身低频振动后小脑神经元结构及多种氧化还原酶活性的变化]

[Changes in neuronal structure and activity of various oxidation- reduction enzymes in the cerebellum after continuous long-term general low-frequency vibration].

作者信息

Il'in I I, Nasibullin B A, Zherebitskiĭ V A

出版信息

Arkh Anat Gistol Embriol. 1991 Feb;100(2):9-15.

PMID:2053887
Abstract

In 84 white non-inbred rats, subjected to the effect of total continuous low-frequency vibration (8 Hz, 95 dB) for 1, 3, 7, 14, 20, 30 days, morphological and histoenzymatic changes have been studied in the nuclear neurons and in the cerebellar cortex. The former are presented as axonal reactions, as chromatolysis of various degree of manifestation, as changes in amount of hypochromic neurons, as glial reactions of various forms. They are interpreted as reactive and are of stage character. The histoenzymatic changes of the oxidation-reduction enzymes come to alterations in the activity of NAD and NADPH-dependent enzymes ratio and possible transformation of the cycle of tricarboxylic acids into the "incomplete" one. The structural and histoenzymatic changes correlate with each other.

摘要

对84只白色非近交系大鼠施加连续的总低频振动(8赫兹,95分贝),分别作用1、3、7、14、20、30天,研究了其核神经元和小脑皮质的形态学及组织酶学变化。前者表现为轴突反应、不同程度表现的染色质溶解、低色神经元数量的变化以及各种形式的神经胶质反应。它们被解释为反应性的,具有阶段性特征。氧化还原酶的组织酶学变化表现为NAD和NADPH依赖性酶活性比例的改变以及三羧酸循环可能转变为“不完全”循环。结构和组织酶学变化相互关联。

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