Department of Psychiatry, San Francisco VA Medical Center, University of California, San Francisco, California, USA.
Nat Protoc. 2010 Jun;5(6):1160-8. doi: 10.1038/nprot.2010.67. Epub 2010 Jun 3.
In this paper, we present a vocal production protocol for studying the neurophysiological action of the corollary discharge, a mechanism that allows animals to ignore sensations resulting from their own actions, and tag them as 'self'. Electroencephalograms are recorded while subjects say 'ah' about 100 times with minimal throat, jaw and tongue movements (Talk condition). This sequence of sounds is recorded and played back during the Listen condition. Event-related potentials are synchronized to the onset of speech sounds during the Talk and Listen conditions. Neural responses from the auditory cortex to the spoken sound as it is being spoken during the Talk condition are compared with neural responses to the same sounds when played back during the Listen condition. The successful action of the corollary discharge is seen when the response of the auditory cortex is suppressed during the Talk compared with the Listen condition. The protocol takes about 5 min to complete.
在本文中，我们提出了一个发声协议，用于研究副言语放电的神经生理作用，这是一种使动物忽略自身行为产生的感觉并将其标记为“自我”的机制。在记录脑电图的同时，被试者以最小的喉咙、下巴和舌头运动说“啊”大约 100 次（说话条件）。在听条件下，记录并播放这段声音序列。在说话和听条件下，事件相关电位与语音的起始同步。将在说话条件下听觉皮层对说话声音的神经反应与在听条件下回放相同声音时的神经反应进行比较。当听觉皮层在说话时的反应在说话时与听时相比受到抑制时，副言语放电的成功作用就会显现出来。该协议大约需要 5 分钟完成。
