Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Analyst. 2010 Sep;135(9):2179-89. doi: 10.1039/c0an00239a. Epub 2010 Jun 11.
Conjugated polymers recently have drawn much attention as an emerging sensory material due to their meritorious signal amplification, convenient optical detection, readily tunable properties, and easy fabrication. We review the molecular design principles of sensory conjugated polymer recognition events, which can trigger conformational change of the conjugated polymer, induce intermolecular aggregation, or change the distance between the conjugated polymer as an energy donor and the reporter dye molecule as an energy acceptor. These recognition/detection mechanisms result in mainly three types of measurable signal generation: turn on or turn off fluorescence, or change in either visible color or fluorescence emission color of the conjugated polymer. In this article, we highlight recent advances in fluorescent and colorimetric conjugated polymer-based biosensors.
共轭聚合物由于其出色的信号放大、方便的光学检测、易于调节的性质和易于制造，最近作为一种新兴的传感材料引起了广泛关注。我们综述了传感共轭聚合物识别事件的分子设计原理，这些识别事件可以引发共轭聚合物的构象变化、诱导分子间聚集、或改变共轭聚合物作为能量供体和报告染料分子作为能量受体之间的距离。这些识别/检测机制主要产生三种可测量的信号生成类型：荧光的开启或关闭，或共轭聚合物的可见颜色或荧光发射颜色的变化。在本文中，我们重点介绍了荧光和比色法基于共轭聚合物的生物传感器的最新进展。
