Department of Otorhinolaryngology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck Austria.
Malar J. 2010 Jun 11;9:159. doi: 10.1186/1475-2875-9-159.
Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice.
Twenty mice were included in a standardized murine cerebral malaria model. Auditory evoked brainstem responses were assessed before infection and at the peak of the illness.
A significant hearing impairment could be demonstrated in mice with malaria, especially the cerebral form. The control group did not show any alterations. No therapy was used.
This suggests that malaria itself leads to a hearing impairment in mice.
恶性疟原虫疟疾已被怀疑可导致听力损失。在患有脑型疟疾的儿童中观察到发育、认知和语言障碍。本前瞻性研究旨在评估疟疾是否会影响小鼠的听力。
20 只小鼠纳入标准化的鼠脑型疟疾模型。在感染前和疾病高峰期评估听觉诱发脑干反应。
在患有疟疾的小鼠中，特别是脑型疟疾的小鼠中，可明显发现听力受损。对照组没有显示任何变化。未使用任何治疗方法。
这表明疟疾本身可导致小鼠听力受损。
