Volgushev S A, Kosykh V A, Podrez E A, Novikov D K, Khlynin S M, Karpov R S
Biull Eksp Biol Med. 1991 Mar;111(3):254-6.
In our study the influence of oxidated cholesterol derivatives (7 alpha, 7 beta-oxicholesterol, 7-ketocholesterol, cholestene-3-one) on binding and degradation of beta-VLDL by human and rabbit hepatocytes was investigated. Cholesterol oxy derivatives inhibit the degradation of beta-VLDL in rabbit hepatocyte culture. There is no such effect with human hepatocytes. However beta-VLDL binding with human hepatocytes is significantly decreased under oxidated cholesterol derivatives influence.
在我们的研究中，研究了氧化胆固醇衍生物（7α, 7β-氧化胆固醇、7-酮胆固醇、胆甾烯-3-酮）对人和兔肝细胞结合及降解β-VLDL的影响。胆固醇氧化衍生物抑制兔肝细胞培养物中β-VLDL的降解。对人肝细胞则无此作用。然而，在氧化胆固醇衍生物的影响下，β-VLDL与人肝细胞的结合显著减少。
