Institute of Psychological Sciences, University of Leeds, Leeds, UK.
World J Biol Psychiatry. 2010 Sep;11(6):824-33. doi: 10.3109/15622975.2010.484550.
There is mixed evidence of association of serotoninergic genes with anorexia nervosa (AN), but substantial evidence for the involvement of serotonergic mechanisms in appetite control. This study was designed to investigate possible associations between the two subtypes of AN (Restricting-RAN, and Binge-purging-BPAN) and polymorphisms within five genes encoding for proteins involved in the serotoninergic system.
In order to carry out this investigation we have conducted a case-control association study on 226 females meeting the criteria for AN, and 678 matched healthy females.
Our data show a significant association between polymorphisms with the gene encoding HTR2A with both AN subtypes, an association between polymorphisms within the genes encoding HTR1D and HTR1B with RAN, and an association between polymorphisms within the gene encoding HTR2C with BPAN. No associations were found for any polymorphisms of the serotonin transporter gene. This outcome indicates a substantial and complex inter-relationship between serotoninergic genes and AN.
Given these data we hypothesis that the expression or control of expression of several genes of the serotoninergic system, and interactions between these genes, could exert considerable influence over the specific symptomatology of the subtypes of AN.
血清素能基因与厌食症（AN）之间的关联存在混合证据，但大量证据表明血清素能机制参与了食欲控制。本研究旨在调查参与血清素能系统的五个基因中编码蛋白的两种亚型（限制型-RAN 和暴食清除型-BPAN）和多态性之间的可能关联。
为了进行这项研究，我们对 226 名符合 AN 标准的女性和 678 名匹配的健康女性进行了病例对照关联研究。
我们的数据显示，HTR2A 基因编码的多态性与两种 AN 亚型显著相关，HTR1D 和 HTR1B 基因编码的多态性与 RAN 相关，HTR2C 基因编码的多态性与 BPAN 相关。5-羟色胺转运体基因的任何多态性均未发现关联。这一结果表明，血清素能基因与 AN 之间存在复杂的相互关系。
鉴于这些数据，我们假设，几种血清素能系统基因的表达或表达控制，以及这些基因之间的相互作用，可能对 AN 亚型的特定症状产生相当大的影响。
