Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
Int J Eat Disord. 2012 May;45(4):556-61. doi: 10.1002/eat.22001. Epub 2012 Jan 24.
The serotonin system has been implicated in mood and appetite regulation, and the serotonin transporter gene (SLC6A4) is a commonly studied candidate gene for eating pathology. However, most studies have focused on a single polymorphism (5-HTTLPR) in SLC6A4; little research has utilized multiple single nucleotide polymorphisms (SNPs) to investigate associations between SLC6A4 and eating pathology more comprehensively.
Family-based association tests were conducted for seven polymorphisms in or near SLC6A4, using families from the Colorado Center for Antisocial Drug Dependence. Data were available for 135 families, with phenotypic data available for female twins and female nontwin siblings. Seven items assessed two disordered eating characteristics: weight and shape concerns and behaviors (WSCB) and binge eating (BE).
No significant associations were found between any genetic variant and the two disordered eating characteristics.
This study suggests that utilizing polymorphisms in and near SLC6A4, including 5-HTTLPR, may not be useful in identifying genetic risk factors for disordered eating.
血清素系统与情绪和食欲调节有关，血清素转运蛋白基因（SLC6A4）是研究饮食病理学的常见候选基因。然而，大多数研究都集中在 SLC6A4 中的单个多态性（5-HTTLPR）上；很少有研究利用多个单核苷酸多态性（SNP）更全面地研究 SLC6A4 与饮食病理学之间的关联。
使用来自科罗拉多反社会药物依赖中心的家庭，对 SLC6A4 内或附近的七个多态性进行基于家庭的关联测试。共有 135 个家庭提供了数据，其中包括女性双胞胎和女性非双胞胎兄弟姐妹的表型数据。有七个项目评估了两种饮食失调特征：体重和体型关注及行为（WSCB）和暴食（BE）。
没有发现任何遗传变异与这两种饮食失调特征之间存在显著关联。
这项研究表明，利用 SLC6A4 内或附近的多态性，包括 5-HTTLPR，可能无法识别饮食失调的遗传风险因素。
