Mangano Carlo, Piattelli Adriano, Tettamanti Lucia, Mangano Francesco, Mangano Alessandro, Borges Fábio, Iezzi Giovanna, d'Avila Susana, Shibli Jamil Awad
Department of Biomaterial Sciences, Insubria University, Varese, Italy.
J Oral Implantol. 2010;36(6):491-6. doi: 10.1563/AAID-JOI-D-09-00028. Epub 2010 Jun 14.
Several regenerative therapies have been used for maxillary sinus grafting. However, recent advances in modern bone tissue engineering techniques have been evaluated. The aim of this histologic report was to evaluate the bone obtained by a culture of autogenous osteoblasts seeded on polyglycolic-polylactid scaffolds in maxillary sinus augmentation. A 56-year-old partially edentulous male with severe atrophy of the posterior maxilla received 6 polyglycolid-polylactid disks (8 mm diameter × 2 mm depth, Oral Bone), each carrying 1.5 million autogenous osteoblasts into the depth of the sinus cavity. After 6 months healing, a bone core was harvested and histologically evaluated. The augmented maxillary sinus with engineered bone presented a mean of 28.89% and 71.11% of bone and medullary spaces, respectively. Data from this case report demonstrate that the newly formed bone provided by engineered bone tissue allowed proper initial stability for dental implant placement. However, the role of this new bone in the long-term success of dental implant anchorage needs further investigation.
几种再生疗法已用于上颌窦植骨。然而，现代骨组织工程技术的最新进展已得到评估。本组织学报告的目的是评估在上颌窦增高术中，接种于聚乙醇酸-聚乳酸支架上的自体成骨细胞培养所获得的骨。一名56岁的部分牙列缺失男性，上颌后部严重萎缩，将6个聚乙醇酸-聚乳酸盘（直径8毫米×深度2毫米，口腔骨）植入鼻窦腔深部，每个盘携带150万个自体成骨细胞。愈合6个月后，采集骨芯并进行组织学评估。用工程骨增高的上颌窦中，骨和骨髓腔的平均占比分别为28.89%和71.11%。该病例报告的数据表明，工程骨组织提供的新形成骨为牙种植体植入提供了适当的初始稳定性。然而，这种新骨在牙种植体锚固长期成功中的作用需要进一步研究。
