Lauritano D, Bignozzi C A, Pazzi D, Cura F, Carinci F
Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza, Italy.
Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Oral Implantol (Rome). 2017 Apr 10;10(1):1-10. doi: 10.11138/orl/2017.10.1.001. eCollection 2017 Jan-Mar.
Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection.
In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an model.
Twenty implants were coated in the internal chamber with PXT and twenty were used as controls.
Ten of the coated implants, preliminarily tested against Gram positive and negative bacteria and fungi, showed a complete inactivation of the microbial species after a 15 min contact. On the remaining ten treated implants a series of microbiological tests and PCR analysis, after contamination of the implant external medium, in which the implant have been immersed, with genetic modified (TF) and (PG), leads to the conclusion that the coating is capable of inactivating the microbial species penetrating the internal of the implant through the implant abutment junction.
钛是牙种植体的金标准，因为它已证明具有出色的生物相容性和骨整合特性。然而，骨整合速率受表面形态影响，种植体周围感染可能影响种植体固定以及长期骨整合结果。因此，种植体-基台连接处（IAJ）表面涂层的化学成分有望在预防细菌感染方面发挥关键作用。
在本研究中，一种用葡萄糖酸洗必泰（PXT）功能化的新型抗菌聚硅氧烷涂层已在一个模型中进行了测试。
二十个种植体在内腔中用PXT涂层，二十个用作对照。
对十个涂层种植体进行初步测试，检测其对革兰氏阳性菌、革兰氏阴性菌和真菌的抗菌效果，结果显示接触15分钟后微生物完全失活。对其余十个处理过的种植体，在将种植体浸入其中的外部培养基被转基因粪肠球菌（TF）和牙龈卟啉单胞菌（PG）污染后，进行了一系列微生物学测试和PCR分析，得出的结论是该涂层能够使通过种植体-基台连接处穿透种植体内部的微生物失活。
