The University of Kansas Medical Center, 3901 Rainbow Blvd, Lied G015, Kansas City, KS, 66160, USA.
Curr Drug Targets. 2010 Sep;11(9):1147-56. doi: 10.2174/138945010792006843.
The hypothesis that tumors may originate from a rare population of cancer stem cells (CSCs) has gained tremendous popularity in recent years and is supported extensively by several pioneering works. Cancer therapies targeting CSCs have unlimited potential for relapse free survival of cancer patients. As a result, knowledge of biological pathways that govern CSCs is very important and this review is focused on the biology of CSCs with special emphasis on breast CSCs, and recent advances in therapeutic approaches targeting them.
近年来，肿瘤可能起源于极少数癌症干细胞（CSC）的假说已广受欢迎，并得到了几项开创性工作的广泛支持。针对 CSC 的癌症疗法为癌症患者的无复发生存提供了无限的潜力。因此，了解控制 CSC 的生物学途径非常重要，本综述重点介绍了 CSC 的生物学特性，特别强调了乳腺癌 CSC，以及针对它们的治疗方法的最新进展。
