Division of Gastroenterology, University of Florida College of Medicine/Jacksonville, Jacksonville, Florida, USA.
Dis Esophagus. 2010 Nov;23(8):609-12. doi: 10.1111/j.1442-2050.2010.01076.x.
Ambulatory esophageal pH monitoring is the current gold standard diagnostic exam for gastroesphageal reflux disease. Presently, no data are available for normal 24-hour esophageal pH monitoring among any US ethnic group. The aim of the present study was to obtain normal values of 24-hour esophageal pH monitoring in healthy adult African American (AA) volunteers and compare these with values obtained in healthy non-Hispanic white (nHw) volunteers to determine if ethnic variation exists in 24-hour esophageal pH testing. Twenty-four-hour dual esophageal pH monitoring was performed in healthy AA and nHw. Values for total number of reflux episodes, episodes longer than 5 min, total reflux time in minutes, and longest reflux episode in the proximal and distal esophagus were obtained for both ethnic groups. Differences between groups were considered significant if P < 0.05. Eighty subjects volunteered for the study and completed 24-hour pH testing. Forty-one were AAs and 39 were nHws, with males making up 49% of each group. The AAs were older and had higher body mass index than the nHws. No difference was observed between the AA and the nHw subjects for any measured pH parameter in either the proximal or distal esophagus. There is no difference in values obtained during esophageal pH monitoring in healthy African Americans and non-Hispanic whites. This indicates that the currently accepted normal values of ambulatory esophageal pH monitoring are readily applicable to African Americans and can be used without compromising diagnostic accuracy in this ethnic group.
动态食管 pH 监测是目前胃食管反流病的金标准诊断检查。目前，在美国任何一个种族群体中，都没有关于正常 24 小时食管 pH 监测的相关数据。本研究的目的是获得健康的非裔美国（AA）志愿者 24 小时食管 pH 监测的正常值，并与健康的非西班牙裔白人（nHw）志愿者的正常值进行比较，以确定 24 小时食管 pH 检测是否存在种族差异。对健康的 AA 和 nHw 志愿者进行 24 小时双食管 pH 监测。记录两组总反流次数、持续时间超过 5 分钟的反流次数、总反流时间（分钟）和近端及远端食管最长反流时间。两组间差异有统计学意义（P<0.05）。共有 80 名志愿者参加了这项研究，并完成了 24 小时 pH 测试。其中 41 名是 AA，39 名是 nHw，每组中男性占 49%。AA 比 nHw 年龄更大，体重指数更高。在近端或远端食管，AA 和 nHw 受试者在任何 pH 参数上均无差异。健康的非裔美国人和非西班牙裔白人在食管 pH 监测中获得的值没有差异。这表明，目前接受的动态食管 pH 监测正常值可以很好地应用于非裔美国人，并且在该种族群体中不会影响诊断准确性。
