肠杆菌科耶尔森氏菌 1B 生物型 blaA 和 blaBβ-内酰胺酶对抗生素敏感性的贡献。
Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B.
机构信息
Microbiology Graduate Group, University of California at Davis, Davis, CA, USA.
出版信息
Antimicrob Agents Chemother. 2010 Sep;54(9):4000-2. doi: 10.1128/AAC.01754-09. Epub 2010 Jun 14.
Abstract
Highly pathogenic Yersinia enterocolitica biovar 1B produces two distinct beta-lactamases, BlaA and BlaB. Mutants of a representative biovar 1B isolate were constructed and evaluated to determine the extent of limitation of susceptibility to broad-spectrum beta-lactam antibiotics by BlaA and BlaB. The results demonstrated that BlaA, a class A enzyme, plays a significant role in limiting susceptibility to penicillins and cephalosporins. The contribution of BlaB, a class C enzyme, was less profound and was limited primarily to cephalosporin susceptibility.
摘要
高致病性小肠结肠炎耶尔森菌生物型 1B 产生两种不同的β-内酰胺酶，BlaA 和 BlaB。构建并评估了代表性生物型 1B 分离株的突变体，以确定 BlaA 和 BlaB 对广谱β-内酰胺类抗生素敏感性的限制程度。结果表明，BlaA 为 A 类酶，在限制青霉素和头孢菌素的敏感性方面发挥重要作用。BlaB 的作用（C 类酶）则不那么显著，主要局限于头孢菌素的敏感性。
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