糖尿病患者血清胱抑素C水平与冠状动脉疾病之间无关联。
Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients.
作者信息
Kim Eun Hee, Yu Ji Hee, Lee Sang Ah, Kim Eui Young, Kim Won Gu, Lee Seung Hun, Cho Eun Hee, Koh Eun Hee, Lee Woo Je, Kim Min-Seon, Park Joong-Yeol, Lee Ki-Up
机构信息
Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
出版信息
Korean Diabetes J. 2010 Apr;34(2):95-100. doi: 10.4093/kdj.2010.34.2.95. Epub 2010 Apr 30.
BACKGROUND
Serum cystatin C level is a more sensitive marker of renal dysfunction than serum creatinine level. Serum cystatin C level was recently reported to predict the development of cardiovascular disease. This study was performed to evaluate whether the cystatin C level is associated with coronary artery disease (CAD), independent of diabetic nephropathy.
METHODS
We conducted a case-control study to assess the relationship between serum cystatin C level and coronary artery disease in diabetic patients. Among 460 diabetic patients, 38 diabetic patients had CAD. The control group consisted of 38 diabetic patients who were matched to cases by age, sex, and presence/absence of diabetic nephropathy. Serum cystatin C level was measured in stored samples.
RESULTS
Serum cystatin C level was significantly higher in patients with diabetic nephropathy, both in CAD and non-CAD patients. However, serum cystatin C level did not differ between CAD and non-CAD patients, regardless of diabetic nephropathy.
CONCLUSION
Serum cystatin C level is a marker of renal dysfunction, but not coronary artery disease, in diabetic patients.
背景
血清胱抑素C水平是比血清肌酐水平更敏感的肾功能不全标志物。最近有报道称血清胱抑素C水平可预测心血管疾病的发生。本研究旨在评估胱抑素C水平是否与冠状动脉疾病（CAD）相关，而不受糖尿病肾病的影响。
方法
我们进行了一项病例对照研究，以评估糖尿病患者血清胱抑素C水平与冠状动脉疾病之间的关系。在460例糖尿病患者中，38例患有CAD。对照组由38例年龄、性别及是否患有糖尿病肾病与病例相匹配的糖尿病患者组成。在储存样本中检测血清胱抑素C水平。
结果
无论CAD患者还是非CAD患者，糖尿病肾病患者的血清胱抑素C水平均显著更高。然而，无论是否患有糖尿病肾病，CAD患者与非CAD患者的血清胱抑素C水平并无差异。
结论
血清胱抑素C水平是糖尿病患者肾功能不全的标志物，但不是冠状动脉疾病的标志物。
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