紫外线A1光疗在顽固性皮肤病中的疗效。
Efficacy of ultraviolet A1 phototherapy in recalcitrant skin diseases.
作者信息
Suh Kee Suck, Kang Jin Seuk, Baek Jae Woo, Kim Tae Kwon, Lee Jin Woo, Jeon Young Seung, Jang Min Soo, Kim Sang Tae
机构信息
Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
出版信息
Ann Dermatol. 2010 Feb;22(1):1-8. doi: 10.5021/ad.2010.22.1.1. Epub 2010 Feb 28.
BACKGROUND
Ultraviolet (UV) radiation has been used for decades to treat a variety of skin diseases. UVA1 was used initially as an effective treatment for acute exacerbated atopic dermatitis. Since then, UVA1 has been attempted for recalcitrant skin diseases.
OBJECTIVE
This study examined the efficacy of UVA1 phototherapy in three recalcitrant skin diseases.
METHODS
This retrospective study reviewed the efficacy and follow-up of 26 patients with atopic dermatitis (AD), mycosis fungoides (MF) and localized scleroderma (LS). SUPUVASUN 3000 (Mutzhas Co., Munich, Germany) and SELLAMED 3000 (Sellas Medizinische Gerate GmbH, Gevelsberg, Germany) were the UVA1 equipment used. Irradiation was performed in accordance with the disease. Low-dose (20 J/cm(2)), medium-dose (65 J/cm(2)) and high-dose regimens (100 J/cm(2)) of UVA1 therapy were employed. The frequency of the therapy ranged from 3 to 5 times weekly. The therapeutic effectiveness was assessed according to the clinical examination before and after the last treatment.
RESULTS
In patients with AD, complete and partial remission was achieved in four (80%) and one (20%) patient, respectively. In patients with MF, complete and partial remission was observed in thirteen (86.7%) and two (13.3%) patients, respectively. In patients with LS, complete and partial remission was observed in three (50%) and three (50%) patients, respectively.
CONCLUSION
UVA1 phototherapy is an effective treatment modality for acute exacerbated AD, MF and LS.
背景
紫外线（UV）辐射已被用于治疗各种皮肤疾病数十年。UVA1最初被用作急性加重性特应性皮炎的有效治疗方法。从那时起，UVA1已被尝试用于治疗顽固性皮肤病。
目的
本研究探讨UVA1光疗对三种顽固性皮肤病的疗效。
方法
这项回顾性研究回顾了26例特应性皮炎（AD）、蕈样肉芽肿（MF）和局限性硬皮病（LS）患者的疗效及随访情况。使用的UVA1设备为SUPUVASUN 3000（德国慕尼黑Mutzhas公司）和SELLAMED 3000（德国盖韦尔斯贝格Sellas Medizinische Gerate GmbH公司）。根据疾病情况进行照射。采用低剂量（20 J/cm²）、中剂量（65 J/cm²）和高剂量（100 J/cm²）的UVA1治疗方案。治疗频率为每周3至5次。根据最后一次治疗前后的临床检查评估治疗效果。
结果
AD患者中，分别有4例（80%）完全缓解和1例（20%）部分缓解。MF患者中，分别有13例（86.7%）完全缓解和2例（13.3%）部分缓解。LS患者中，分别有3例（50%）完全缓解和3例（50%）部分缓解。
结论
UVA1光疗是治疗急性加重性AD、MF和LS的有效治疗方式。
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