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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Reid M A, Mather L E, Runciman W B, McLean C F

Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Flinders University of South Australia, Adelaide.

Clin Exp Pharmacol Physiol. 1991 Mar;18(3):169-78. doi: 10.1111/j.1440-1681.1991.tb01428.x.

The reliability of the Kety-Schmidt nitrous oxide (N2O) blood-tissue equilibration method was examined in 50 studies of myocardial blood flow in seven conscious, unrestrained sheep using a newly developed carefully validated gas chromatographic assay for N2O. 2. In 10 studies the arterial and coronary sinus N2O blood concentration-time curves converged as expected at the end of the 10 min sampling period. In 14 studies they crossed over, and in 26 studies, the curves failed to converge. 3. A survey of the literature revealed that such results have been encountered previously but have not been accorded particular significance. An ultimate matching equilibrium between arterial and venous blood N2O concentration-time curves is, however, fundamental to the validity of the method. 4. The results indicate that the use of the Kety-Schmidt method with N2O as the indicator gas is invalid as applied to the measurement of myocardial blood flow in this preparation.

采用新开发的经过严格验证的一氧化二氮气相色谱分析法，在7只清醒、未受束缚的绵羊身上进行了50项心肌血流研究，以此检验凯蒂-施密特一氧化二氮（N2O）血液-组织平衡法的可靠性。2. 在10项研究中，动脉血和冠状窦血中N2O的浓度-时间曲线在10分钟采样期结束时如预期那样趋于一致。在14项研究中，它们出现了交叉，在26项研究中，曲线未能趋于一致。3. 文献调查显示，此前也曾遇到过此类结果，但未给予特别关注。然而，动脉血和静脉血N2O浓度-时间曲线最终达到匹配平衡是该方法有效性的根本所在。4. 结果表明，将以N2O作为指示气体的凯蒂-施密特方法应用于该制剂中心肌血流的测量是无效的。

Reid M A, Mather L E, Runciman W B, McLean C F

Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Flinders University of South Australia, Adelaide.

Clin Exp Pharmacol Physiol. 1991 Mar;18(3):169-78. doi: 10.1111/j.1440-1681.1991.tb01428.x.

The reliability of the Kety-Schmidt nitrous oxide (N2O) blood-tissue equilibration method was examined in 50 studies of myocardial blood flow in seven conscious, unrestrained sheep using a newly developed carefully validated gas chromatographic assay for N2O. 2. In 10 studies the arterial and coronary sinus N2O blood concentration-time curves converged as expected at the end of the 10 min sampling period. In 14 studies they crossed over, and in 26 studies, the curves failed to converge. 3. A survey of the literature revealed that such results have been encountered previously but have not been accorded particular significance. An ultimate matching equilibrium between arterial and venous blood N2O concentration-time curves is, however, fundamental to the validity of the method. 4. The results indicate that the use of the Kety-Schmidt method with N2O as the indicator gas is invalid as applied to the measurement of myocardial blood flow in this preparation.

采用新开发的经过严格验证的一氧化二氮气相色谱分析法，在7只清醒、未受束缚的绵羊身上进行了50项心肌血流研究，以此检验凯蒂-施密特一氧化二氮（N2O）血液-组织平衡法的可靠性。2. 在10项研究中，动脉血和冠状窦血中N2O的浓度-时间曲线在10分钟采样期结束时如预期那样趋于一致。在14项研究中，它们出现了交叉，在26项研究中，曲线未能趋于一致。3. 文献调查显示，此前也曾遇到过此类结果，但未给予特别关注。然而，动脉血和静脉血N2O浓度-时间曲线最终达到匹配平衡是该方法有效性的根本所在。4. 结果表明，将以N2O作为指示气体的凯蒂-施密特方法应用于该制剂中心肌血流的测量是无效的。