Experimental Surgery Laboratory, European Institute for Peptide Research (IFRMP 23), University of Rouen, 22 boulevard Gambetta, 76183 Rouen, France.
Glia. 2010 Oct;58(13):1570-80. doi: 10.1002/glia.21030.
Olfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source for OECs. Many studies have compared the distinct ability of OECs from OB and OM to improve functional nerve regeneration after lesion of the nervous system. Nevertheless, the two populations of OECs may differ in several points, which might affect all fate after transplantation in vivo. We report here the first study which compares gene expression profiling between these two populations of OECs. It appears that OB-OECs and OM-OECs display distinct gene expression pattern, which suggest that they may be implicated in different physiological processes. Notably, OM-OECs overexpress genes characteristic of wound healing and regulation of extra cellular matrix. In contrast, OB-OECs gene profile suggests a prominent role in nervous system development. Hence, OB-OECs and OM-OECs fundamentally differ in their gene expression pattern, which may represent a crucial point for future clinical application.
嗅鞘细胞（OEC）具有促进神经系统再生的能力。因此，它们有望用于细胞治疗。大多数实验研究都调查了从嗅球（OB）中提取的 OEC 的作用。然而，对于临床应用，嗅黏膜（OM）似乎是 OEC 的唯一可接受来源。许多研究比较了 OB 和 OM 来源的 OEC 在神经系统损伤后改善功能神经再生的不同能力。然而，这两种 OEC 群体在多个方面可能存在差异，这可能会影响体内移植后的所有命运。我们在这里报告了第一项比较这两种 OEC 群体之间基因表达谱的研究。结果表明，OB-OEC 和 OM-OEC 表现出不同的基因表达模式，这表明它们可能参与不同的生理过程。值得注意的是，OM-OEC 过度表达与伤口愈合和细胞外基质调节相关的基因。相比之下，OB-OEC 的基因谱表明其在神经系统发育中具有重要作用。因此，OB-OEC 和 OM-OEC 在基因表达模式上存在根本差异，这可能是未来临床应用的关键。
