Stepanova N V, Filimonov V I
Fiziol Zh (1978). 1991 Mar-Apr;37(2):19-24.
The experiment on rats and mice has shown that the presence of a developing callus in the organism after fracture of the tubular bones inhibits erythropoiesis. Inhibition of erythropoiesis is due to delay of erythropoietin biosynthesis by serotonin. A problem on two-fold serotonin effect is under discussion: on the one hand, serotonin inhibits the erythropoietin formation and delays erythropoiesis, on the other hand, it intensifies the effect of ready erythropoietin on the developing bone marrow erythroid cells.
对大鼠和小鼠的实验表明，管状骨骨折后机体中正在形成的骨痂会抑制红细胞生成。红细胞生成的抑制是由于血清素延迟了促红细胞生成素的生物合成。目前正在讨论血清素的双重作用问题：一方面，血清素抑制促红细胞生成素的形成并延迟红细胞生成，另一方面，它增强了现成的促红细胞生成素对发育中的骨髓红细胞系细胞的作用。
