Stanford, Calif.; and Heidelberg, Germany From the Hagey Laboratory for Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, and Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; and the BG-Unfallklinik Ludwigshafen, Department of Plastic and Hand Surgery, University of Heidelberg.
Plast Reconstr Surg. 2010 Oct;126(4):1163-1171. doi: 10.1097/PRS.0b013e3181ea42bb.
Stem cells are self-renewing cells capable of differentiating into multiple cell lines and are classified according to their origin and their ability to differentiate. Enormous potential exists in use of stem cells for regenerative medicine. To produce effective stem cell-based treatments for a range of diseases, an improved understanding of stem cell biology and better control over stem cell fate are necessary. In addition, the barriers to clinical translation, such as potential oncologic properties of stem cells, need to be addressed. With renewed government support and continued refinement of current stem cell methodologies, the future of stem cell research is exciting and promises to provide novel reconstructive options for patients and surgeons limited by traditional paradigms.
干细胞是自我更新的细胞，能够分化为多种细胞系，并根据其起源和分化能力进行分类。干细胞在再生医学中的应用具有巨大的潜力。为了针对一系列疾病产生有效的基于干细胞的治疗方法，需要更好地了解干细胞生物学并更好地控制干细胞命运。此外，还需要解决临床转化的障碍，例如干细胞的潜在肿瘤特性。随着政府的重新支持和当前干细胞方法的不断完善，干细胞研究的未来令人兴奋，并有望为受传统范例限制的患者和外科医生提供新的重建选择。
