Department for Histology and Embryology and Center for Proteomics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
Curr Opin Microbiol. 2010 Aug;13(4):530-9. doi: 10.1016/j.mib.2010.05.011. Epub 2010 Jun 16.
Since their discovery, our understanding of NK cells has evolved from branding them marginal innate immunity cells to key players in anti-viral and anti-tumor immunity. Importance of NK cells in control of various viral infections is perhaps best illustrated by the existence of plethora of viral mechanisms aimed to modulate their function. These mechanisms include not only virally encoded immunoevasion proteins but also viral miRNA. Moreover, the evidence has been accumulated supporting the role of viral immunoevasion of NK cells in viral pathogenesis in vivo.
自发现以来，我们对自然杀伤 (NK) 细胞的认识已从将其归为边缘固有免疫细胞转变为抗病毒和抗肿瘤免疫的关键细胞。NK 细胞在控制各种病毒感染中的重要性可以通过存在大量旨在调节其功能的病毒机制得到最好的说明。这些机制不仅包括病毒编码的免疫逃逸蛋白，还包括病毒 miRNA。此外，已经积累了支持 NK 细胞的病毒免疫逃逸在体内病毒发病机制中的作用的证据。
