Jacobs-Reitsma W F, Koenraad P M, Bolder N M, Mulder R W
Institute for Animal Science and Health (ID-DLO), Branch Beekbergen, The Netherlands.
Vet Q. 1994 Dec;16(4):206-8. doi: 10.1080/01652176.1994.9694450.
Recently, an increased resistance of Campylobacter to fluoroquinolones, a newer class of antimicrobial agents in both human and veterinary medicine, has been reported. Campylobacter isolates (617) from 150 broiler flocks were tested for their susceptibility to cephalothin (control), ampicillin, tetracycline, erythromycin, and the quinolones nalidixic acid, flumequine, enrofloxacin, and ciprofloxacin by a disc diffusion method. Almost complete cross-resistance was found between the quinolones tested. Campylobacter isolates (181, 29%), originating from 55 flocks (37%), were quinolone resistant. Salmonella isolates (94) from 40 flocks were also tested for their antimicrobial susceptibility. Eight isolates (8.5%), from three broiler flocks (7.5%), showed resistance to nalidixic acid and flumequine (and tetracycline), but not to ciprofloxacin or enrofloxacin.
最近，有报道称弯曲杆菌对氟喹诺酮类药物的耐药性有所增加，氟喹诺酮类是人类医学和兽医学中一类较新的抗菌药物。采用纸片扩散法对来自150个肉鸡群的弯曲杆菌分离株（617株）进行了对头孢噻吩（对照）、氨苄西林、四环素、红霉素以及喹诺酮类药物萘啶酸、氟甲喹、恩诺沙星和环丙沙星的敏感性测试。在所测试的喹诺酮类药物之间发现了几乎完全的交叉耐药性。来自55个鸡群（37%）的弯曲杆菌分离株（181株，占29%）对喹诺酮类药物耐药。还对来自40个鸡群的沙门氏菌分离株（94株）进行了抗菌药敏试验。来自三个肉鸡群（占7.5%）的八株分离株（占8.5%）对萘啶酸和氟甲喹（以及四环素）耐药，但对环丙沙星或恩诺沙星不耐药。
