Vaccine and Gene Therapy Institute, Oregon Health and Science University, United States.
Exp Gerontol. 2010 Sep;45(9):655-61. doi: 10.1016/j.exger.2010.06.001. Epub 2010 Jun 15.
Aging is accompanied by a general dysregulation in immune system function, commonly referred to as 'immune senescence'. This progressive deterioration affects both innate and adaptive immunity, although accumulating evidence indicates that the adaptive arm of the immune system may exhibit more profound changes. Most of our current understanding of immune senescence stems from clinical and rodent studies. More recently, the use of nonhuman primates (NHPs) to investigate immune senescence and test interventions aimed at delaying/reversing age-related changes in immune function has dramatically increased. These studies have been greatly facilitated by several key advances in our understanding of the immune system of old world monkeys, specifically the rhesus macaques. In this review we describe the hallmarks of immune senescence in this species and compare them to those described in humans. We also discuss the impact of immune senescence on the response to vaccination and the efficacy of immuno-restorative interventions investigated in this model system.
衰老是伴随着免疫系统功能的普遍失调而发生的，通常被称为“免疫衰老”。这种进行性恶化影响固有免疫和适应性免疫，尽管越来越多的证据表明，免疫系统的适应性分支可能表现出更深刻的变化。我们目前对免疫衰老的大部分理解源于临床和啮齿动物研究。最近，使用非人类灵长类动物（NHPs）来研究免疫衰老并测试旨在延缓/逆转与年龄相关的免疫功能变化的干预措施的使用显著增加。这些研究得益于我们对旧世界猴子（特别是恒河猴）免疫系统的理解的几个关键进展，极大地促进了这些研究。在这篇综述中，我们描述了该物种免疫衰老的特征，并将其与人类描述的特征进行了比较。我们还讨论了免疫衰老对疫苗反应和该模型系统中研究的免疫修复干预措施疗效的影响。
