California National Primate Research Center, Davis, California, USA.
Department of Psychology, University of California Davis, Davis, California, USA.
Am J Primatol. 2021 Dec;83(12):e23331. doi: 10.1002/ajp.23331. Epub 2021 Sep 20.
Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, animal model for complex metabolic, neurological, and infectious diseases. The increased demand for and limited availability of these valuable research subjects requires that rigor and reproducibility be a prime consideration to ensure the maximal utility of this scarce resource. Here, we discuss a number of approaches that collectively can contribute to enhanced rigor and reproducibility in NHP research.
非人类灵长类动物（NHPs）是转化/临床前生物医学研究的重要组成部分，因为 NHPs 与人类在生理和疾病病理方面具有很强的相似性。在某些情况下，NHPs 是复杂代谢、神经和传染病的最合适的、甚至是唯一的动物模型。对这些宝贵研究对象的需求增加，但数量有限，这要求严格性和可重复性成为首要考虑因素，以确保充分利用这一稀缺资源。在这里，我们讨论了一些可以共同提高 NHPs 研究的严谨性和可重复性的方法。
