Harrington R, Fudge H, Rutter M, Pickles A, Hill J
Department of Psychiatry, Queen Elizabeth Hospital, Edgbaston, Birmingham, England.
J Am Acad Child Adolesc Psychiatry. 1991 May;30(3):434-9. doi: 10.1097/00004583-199105000-00013.
Sixty-three child and adolescent patients meeting operational criteria for depression and 68 non-depressed child psychiatric controls were followed into adulthood. Twenty-one percent of the depressed group had had conduct disorder (CD) in conjunction with their index depression. Depressed children with comorbid CD did not differ from depressed children without conduct problems with respect to depressive symptom presentation or demographic characteristics. However, depressives with CD had a worse short-term outcome and a higher risk of adult criminality than depressed children without conduct problems. There was a strong trend for depressives with CD to have a lower risk of depression in adulthood than depressed children without conduct problems. The outcomes of depressives with CD were very similar to those of nondepressed children with CD. The findings are discussed in the context of current classification schemes.
63名符合抑郁症操作标准的儿童和青少年患者以及68名非抑郁儿童精神科对照被随访至成年期。抑郁症组中有21%在首次患抑郁症时伴有品行障碍(CD)。伴有共病CD的抑郁儿童在抑郁症状表现或人口统计学特征方面与无品行问题的抑郁儿童没有差异。然而,患有CD的抑郁症患者与无品行问题的抑郁儿童相比,短期预后更差,成年后犯罪风险更高。患有CD的抑郁症患者成年后患抑郁症的风险比无品行问题的抑郁儿童有明显降低的趋势。患有CD的抑郁症患者的结局与患有CD的非抑郁儿童非常相似。研究结果在当前分类方案的背景下进行了讨论。