Silvestro L, Viano I, Baiocchi C, Saini G, Marmont F, Ferro R
Istituto di Farmacologia e Terapia Sperimentale, Università di Torino, Italy.
J Chromatogr. 1991 Feb 15;563(2):443-50. doi: 10.1016/0378-4347(91)80054-g.
An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.
开展了一项用于分离和测定人血浆中美法仑的分析程序。利用电极氧化还原反应的高灵敏度，开发了一种采用电化学检测的简单高效液相色谱法。由于该药物提取困难，样品预处理采用直接提取干扰物而非美法仑的方式，且非常简单、快速且可重复。
