Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan.
Phytother Res. 2010 Aug;24(8):1250-5. doi: 10.1002/ptr.3196.
Berberis vulgaris is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous-methanol extract of Berberis vulgaris root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg/kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity-guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis.
小檗是一种被广泛用于治疗尿路结石的植物。为了评估其抗尿路结石的潜力，我们在雄性 Wistar 大鼠的尿路结石动物模型中对小檗根皮的粗水-甲醇提取物（Bv.Cr）进行了测试，该模型通过在饮用水中添加 0.75%的乙二醇来建立。Bv.Cr（50mg/kg）抑制了肾小管中 CaOx 晶体的沉积，并防止了多尿、体重减轻、肾功能受损以及肾脏氧化应激的发展等相关变化。基于活性的分级分离显示，抗尿路结石成分主要存在于水相部分。这些数据表明小檗根皮中存在抗尿路结石活性，这为其在尿路结石治疗中的药用提供了依据。
