Sarfaraz Sunny, Sund Zoe, Jarad Nabil
Adult CF Centre, Department of Respiratory Medicine, Bristol Royal Infirmary, Bristol, UK.
Clin Respir J. 2010 Apr;4(2):74-82. doi: 10.1111/j.1752-699X.2009.00147.x.
We investigated feasibility and value of a real-time electronic monitoring system adapted for early detection of cystic fibrosis (CF) pulmonary exacerbations (P Exs).
This was a 6-month prospective study. Patients recorded once daily their symptom score and spirometry using an electronic diary. The data were sent daily to the research team in real time. P Ex was considered to be present when change in symptoms and lung function values met a preset criteria. Number of P Exs during the study was compared with a parallel period of the previous and of the following years.
Only 19 patients (37.2%) completed recording that could be evaluated. A total of 53 P Exs were identified, 26 (49.0%) of which needed intravenous (IV) antibiotics. The number of total P Exs in the study year did not differ from the previous or the following year, but the number of courses of oral antibiotics was greater than those given during the previous year.
Remote daily monitoring of symptoms and spirometry had a poor uptake among CF patients. For those who completed the study, this method early detected P Exs that were treated with oral antibiotics that might otherwise required IV antibiotics.
我们研究了一种适用于早期检测囊性纤维化（CF）肺部加重（P Exs）的实时电子监测系统的可行性和价值。
这是一项为期6个月的前瞻性研究。患者每天使用电子日记记录一次症状评分和肺功能测定值。数据每天实时发送给研究团队。当症状和肺功能值的变化符合预设标准时，即认为存在P Ex。将研究期间的P Exs数量与前一年和后一年的平行时间段进行比较。
只有19名患者（37.2%）完成了可评估的记录。共识别出53次P Exs，其中26次（49.0%）需要静脉注射（IV）抗生素。研究年度的P Exs总数与前一年或后一年没有差异，但口服抗生素疗程的数量多于前一年。
CF患者对症状和肺功能测定值的远程每日监测接受度较低。对于完成研究的患者，这种方法可早期检测出原本可能需要静脉注射抗生素治疗的P Exs，现用口服抗生素治疗。
