Public Health Sciences, University of Edinburgh, Medical School, Edinburgh EH9 1NN, UK.
Behav Genet. 2010 Sep;40(5):630-8. doi: 10.1007/s10519-010-9372-y. Epub 2010 Jun 22.
The dopaminergic neurotransmitter system of the brain is involved in working memory and other cognitive functions. Studies suggest an important role for dopamine synthesis and uptake in modulation of human cognitive processes. We studied the association between polymorphisms in the catechol-o-methyl transferase (COMT) and dopamine receptor D2 (DRD2) genes and general cognitive ability in a secondary analysis of 2091 men and women, aged 55-80 years living in Scotland. General cognitive ability 'g' was derived from five cognitive tests of different domains. COMT was not associated with cognitive ability in this population. The DRD2 C:C genotype of rs6277 was associated with decreased general cognitive ability 'g' (p = 0.003), and DRD2 rs1800497 heterozygotes had lowest mean general cognitive ability 'g' (p = 0.007). There was an indication of a potential interaction between the DRD2 SNPs.
大脑中的多巴胺能神经递质系统参与工作记忆和其他认知功能。研究表明，多巴胺的合成和摄取在调节人类认知过程中起着重要作用。我们研究了在苏格兰生活的 2091 名 55-80 岁的男性和女性中，儿茶酚氧位甲基转移酶（COMT）和多巴胺受体 D2（DRD2）基因的多态性与一般认知能力之间的关系。一般认知能力“g”是从五个不同领域的认知测试中得出的。在该人群中，COMT 与认知能力无关。DRD2 rs6277 的 C:C 基因型与一般认知能力“g”降低相关（p = 0.003），并且 DRD2 rs1800497 杂合子的一般认知能力“g”最低（p = 0.007）。DRD2 SNPs 之间存在潜在相互作用的迹象。
