Prescrire Int. 2010 Apr;19(106):72-3.
Varicella and herpes zoster are due to varicella-zoster virus. Outcome of both infections is generally favourable. The most frequent severe complications are invasive streptococcal and staphylococcal superinfections, especially in children. A nested case-control study conducted within a British cohort showed a statistically significant increase in the risk of severe cutaneous complications in patients with varicella or herpes zoster who took nonsteroidal antiinflammatory drugs (NSAIDs). No such increase was reported in patients who took paracetamol. These findings are in keeping with previously published data. In practice, fever and pain associated with varicella or herpes zoster should be treated with paracetamol, not a NSAID.
水痘和带状疱疹由水痘-带状疱疹病毒引起。两种感染的预后通常良好。最常见的严重并发症是侵袭性链球菌和葡萄球菌的二重感染，尤其是在儿童中。在一个英国队列中进行的一项巢式病例对照研究显示，服用非甾体抗炎药（NSAIDs）的水痘或带状疱疹患者发生严重皮肤并发症的风险有统计学意义的增加。服用对乙酰氨基酚的患者未报告有此类增加。这些发现与先前发表的数据一致。在实际应用中，水痘或带状疱疹相关的发热和疼痛应以对乙酰氨基酚治疗，而非NSAIDs。
