National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan.
Res Vet Sci. 2011 Feb;90(1):20-2. doi: 10.1016/j.rvsc.2010.05.009. Epub 2010 Jun 8.
The pathogenicity of Erysipelothrix tonsillarum was evaluated in pigs immunosuppressed with cyclophosphamide (CY) or dexamethasone (DM). Animals were treated with 15 mg/kg CY (n=8, five injections), 1 mg/kg DM (n=8, nine injections) or left untreated (n=8). On the fifth day after the beginning of drug treatments, swine were inoculated with one of two E. tonsillarum serovar 7 strains (approximately 10(6) CFU per pig). In the CY-treated group, both circulating neutrophil and lymphocyte counts decreased, whereas in the DM-treated group, lymphocyte counts decreased but neutrophil counts increased. During the observation period, none of the CY- or DM-treated pigs developed clinical signs or gross lesions, as well as non-treated pigs. Growth agglutination antibody titres in all pigs remained unchanged. Our findings indicate that E. tonsillarum strains are avirulent for swine, regardless of immune status.
环磷酰胺（CY）或地塞米松（DM）免疫抑制猪的杀白细胞素七型丹毒丝菌致病性评价。动物用 15mg/kgCY（n=8，5 次注射）、1mg/kgDM（n=8，9 次注射）或未处理（n=8）处理。药物治疗开始后的第五天，猪用两种杀白细胞素七型丹毒丝菌血清型 7 株之一接种（每头猪约 10(6)CFU）。在 CY 处理组中，循环中性粒细胞和淋巴细胞计数均下降，而在 DM 处理组中，淋巴细胞计数下降但中性粒细胞计数增加。在观察期间，CY 或 DM 处理的猪均未出现临床症状或大体病变，未处理的猪也未出现。所有猪的生长凝集抗体滴度保持不变。我们的研究结果表明，无论免疫状态如何，杀白细胞素七型丹毒丝菌菌株对猪均无致病性。
