Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy.
Trends Biochem Sci. 2010 Nov;35(11):601-8. doi: 10.1016/j.tibs.2010.05.008. Epub 2010 Jun 8.
Endocannabinoids are key mediators of many aspects of human health and disease. The biological activity of anandamide, a prominent member of this group, depends on the metabolic control exerted by biosynthetic, catabolic and oxidative pathways working together. Cellular uptake and intracellular trafficking of anandamide are crucial steps in the process. Whereas the identity of anandamide transmembrane carriers remains undetermined, recent insights have been gained related to its intracellular stores (adiposomes) and intracellular binding proteins, particularly fatty acid binding proteins, albumin and heat shock protein 70. On this basis, we propose a reconsideration of the dogma that endocannabinoids are exclusively synthesized and released 'on demand', and suggest that their metabolic control is complemented by intracellular trafficking and storage in specific reservoirs.
内源性大麻素是许多人类健康和疾病方面的关键调节物。作为该家族中的重要成员，大麻素的生物活性取决于生物合成、分解代谢和氧化途径共同发挥作用的代谢控制。大麻素的细胞摄取和细胞内转运是该过程的关键步骤。尽管大麻素的跨膜载体的身份尚未确定，但最近在其细胞内储存库（脂肪小体）和细胞内结合蛋白方面取得了一些新的认识，特别是脂肪酸结合蛋白、白蛋白和热休克蛋白 70。在此基础上，我们建议重新考虑内源性大麻素仅在“需要时”合成和释放的这一教条，并提出它们的代谢控制还需要通过特定储库中的细胞内转运和储存来补充。
