Department of Genetics, Yale University, New Haven, USA.
Crit Rev Biochem Mol Biol. 2010 Oct;45(5):331-50. doi: 10.3109/10409238.2010.496772.
Ribonucleoproteins (RNPs) play key roles in many cellular processes and often function as RNP enzymes. Similar to proteins, some of these RNPs exist and function as multimers, either homomeric or heteromeric. While in some cases the mechanistic function of multimerization is well understood, the functional consequences of multimerization of other RNPs remain enigmatic. In this review we will discuss the function and organization of small RNPs that exist as stable multimers, including RNPs catalyzing RNA chemical modifications, telomerase RNP, and RNPs involved in pre-mRNA splicing.
核糖核蛋白（RNP）在许多细胞过程中发挥着关键作用，通常作为 RNP 酶发挥功能。与蛋白质类似，其中一些 RNP 以多聚体的形式存在并发挥功能，无论是同源多聚体还是异源多聚体。虽然在某些情况下，多聚化的机械功能已经得到很好的理解，但其他 RNP 多聚化的功能后果仍然是神秘的。在这篇综述中，我们将讨论作为稳定多聚体存在的小 RNP 的功能和组织，包括催化 RNA 化学修饰的 RNP、端粒酶 RNP 和参与前体 RNA 剪接的 RNP。
