Department of Surgery, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Surg Infect (Larchmt). 2010 Aug;11(4):367-70. doi: 10.1089/sur.2008.084.
The aim of this clinical trial was to determine whether prophylactic antibiotics could prevent surgical site infection (SSI) after laparoscopic cholecystectomy and to identify any risk factors for infection.
The study included 100 patients undergoing laparoscopic cholecystectomy. They were randomized to receive either a single dose of ceftriaxone (Group A; n = 50) or physiologic saline as placebo (Group B; n = 50) after the induction of anesthesia. Patient demographics and clinical and surgical outcomes were recorded.
The incidence of SSI was similar in the two groups: 2 patients in group A and 4 patients in group B (chi(2) = 0.71; p = 0.40). None of the factors studied was associated with surgical site infection statistically, as shown by binary logistic regression analysis.
A single dose of prophylactic antibiotic failed to decrease the likelihood of SSI after laparoscopic cholecystectomy.
本临床试验旨在确定预防性抗生素是否可以预防腹腔镜胆囊切除术后手术部位感染（SSI），并确定感染的任何危险因素。
本研究纳入了 100 例接受腹腔镜胆囊切除术的患者。他们在麻醉诱导后随机分为头孢曲松单次剂量组（A 组，n=50）或生理盐水安慰剂组（B 组，n=50）。记录患者的人口统计学、临床和手术结果。
两组 SSI 的发生率相似：A 组 2 例，B 组 4 例（卡方=0.71；p=0.40）。二元逻辑回归分析显示，研究的任何因素均与手术部位感染无统计学关联。
单次预防性使用抗生素未能降低腹腔镜胆囊切除术后 SSI 的发生几率。
