八鞭毛的生活：贾第虫的鞭毛组装和分裂。
Life with eight flagella: flagellar assembly and division in Giardia.
机构信息
Department of Microbiology, One Shields Avenue, UC Davis, Davis, CA 95616, USA.
出版信息
Curr Opin Microbiol. 2010 Aug;13(4):480-90. doi: 10.1016/j.mib.2010.05.014. Epub 2010 Jun 25.
Abstract
Flagellar movement in Giardia, a common intestinal parasitic protist, is crucial to its survival in the host. Each axoneme is unique in possessing a long, cytoplasmic portion as well as a membrane-bound portion. Intraflagellar transport (IFT) is required for the assembly of membrane-bound regions, yet the cytoplasmic regions may be assembled by IFT-independent mechanisms. Steady-state axoneme length is maintained by IFT and by intrinsic and active microtubule dynamics. Following mitosis and before their segregation, giardial flagella undergo a multigenerational division cycle in which the parental eight flagella migrate and reposition to different cellular locations; eight new flagella are assembled de novo. Each daughter cell thus inherits four mature and four newly synthesized flagella.
摘要
鞭毛运动在贾第虫中，一种常见的肠道寄生原生动物，对其在宿主中的生存至关重要。每个轴丝都有其独特之处，既有长的细胞质部分，也有膜结合部分。鞭毛内运输（IFT）是组装膜结合区域所必需的，然而细胞质区域可能通过 IFT 独立的机制进行组装。稳态轴丝长度通过 IFT 和内在的、活跃的微管动力学来维持。有丝分裂后，在分离之前，贾第虫鞭毛经历一个多代的分裂周期，在此期间，亲代的 8 根鞭毛迁移并重新定位到不同的细胞位置；新组装 8 根鞭毛。因此，每个子细胞继承 4 根成熟的和 4 根新合成的鞭毛。
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