Halberg P, Bendixen G, Kriegbaum N J, Lorenzen I, Müller K, Olesen K M, Ullman S
Hvidovre Hospital, København, reumatologisk afdeling.
Ugeskr Laeger. 1991 Jun 10;153(24):1700-4.
One hundred and seventy-three patients had systemic lupus erythematosus according to the 1982-ARA-criteria. The mean disease duration at the time of the study was 16.4 years, and the patients were followed by three Copenhagen clinics for a mean of 13.9 years until 1987/88 or death. Half of the patients had nephropathy, 61 patients developed severe infections, and 39 patients had thrombotic episodes. Fifty-six patients died during the observation period, 24 due to active lupus (12 of kidney failure), 12 because of infections, and 11 because of atherosclerotic cardio-vascular disease. The patients had 10-, 15- and 20-year survival rates of 80, 65 and 48 per cent. The deaths were evenly distributed throughout the observation period.
根据1982年美国风湿病学会（ARA）标准，173例患者患有系统性红斑狼疮。研究时的平均病程为16.4年，这些患者由哥本哈根的三家诊所随访，平均随访13.9年，直至1987/1988年或死亡。一半的患者患有肾病，61例患者发生严重感染，39例患者出现血栓形成事件。在观察期内，56例患者死亡，24例死于活动性狼疮（12例死于肾衰竭），12例死于感染，11例死于动脉粥样硬化性心血管疾病。患者的10年、15年和20年生存率分别为80%、65%和48%。死亡在整个观察期内分布均匀。
