Department of Parasitology, University of Indonesia, Faculty of Medicine, Salemba Raya, Jakarta, Indonesia.
Int J Parasitol. 2010 Aug 15;40(10):1171-6. doi: 10.1016/j.ijpara.2010.05.003. Epub 2010 May 23.
Parasitic infections are common in many tropical and sub-tropical regions of the world and concomitant infection, polyparasitism, is the rule rather than the exception in such areas. At the immunological level, different parasites induce quite different responses characterised, for example, by protozoa that polarise responses towards Th1, whilst helminths are strong Th2 and regulatory T cell inducers. The question of how the co-existence of such parasites within the same host might influence the immunological responses to each species and, more importantly, whether such interactions affect resistance, susceptibility or clinical outcome, needs to be addressed in well-designed studies of sufficient power. The current paper discusses what we know as well as the gaps in our knowledge of polyparasitism.
寄生虫感染在世界上许多热带和亚热带地区很常见，在这些地区，伴随感染（即多种寄生虫感染）是常见现象而非例外。在免疫学层面，不同寄生虫会引发截然不同的反应，例如，原生动物会使免疫反应向 Th1 极化，而蠕虫则强烈诱导 Th2 和调节性 T 细胞。在同一个宿主中，这些寄生虫共存如何影响对每种寄生虫的免疫反应，以及更重要的是，这种相互作用是否会影响抵抗力、易感性或临床结果，这些问题需要在设计良好、有足够效力的研究中加以解决。本文讨论了我们对多寄生虫感染的了解程度，以及其中的知识空白。
