Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, South Korea.
Laryngoscope. 2010 Jul;120(7):1405-10. doi: 10.1002/lary.20947.
OBJECTIVES/HYPOTHESIS: The purpose of this study was to investigate the effect of topical sodium thiosulfate (STS) in experimentally induced myringosclerosis (MS).
A prospective experimental animal study.
Thirty Wistar albino rats were bilaterally myringotomized. The right ears were treated with STS or saline daily, and the left ears were left untreated and used as controls. The tympanic membranes were observed by otoendoscopy weekly, and tympanometric measurements were performed. All animals were histopathologically examined for myringosclerotic plaques.
Under otoendoscopy, myringosclerosis were observed around the handle of the malleus and near the annular region. The numbers of myringosclerotic ears were significantly more frequent in control and saline groups compared with the STS group (P < .05), and the formation of MS was more severe in control and saline groups compared with STS group (P < .05). Using tympanometric measurement, significantly reduced magnitudes of maximum admittance were observed in control and saline groups compared to normal and STS groups (P < .05). Under histopathologic examination, the tympanic membrane of the STS group appeared thinner than the control group (P < .05), with reduced calcium deposition than control and saline groups.
Our results show that sodium thiosulfate has a preventive role in the development of myringosclerosis in the experimental animal model.
目的/假设：本研究旨在探讨局部硫代硫酸钠（STS）对实验性鼓膜硬化症（MS）的影响。
前瞻性实验动物研究。
30 只 Wistar 白化大鼠双侧鼓膜切开。右耳每日用 STS 或生理盐水处理，左耳未处理作为对照。每周通过耳内镜观察鼓膜，并进行鼓室压测量。对所有动物的鼓膜硬化斑块进行组织病理学检查。
在耳内镜下，观察到锤骨柄周围和环状区域有鼓膜硬化。与 STS 组相比，对照组和生理盐水组出现鼓膜硬化的耳数明显更多（P <.05），对照组和生理盐水组的 MS 形成更严重（P <.05）。通过鼓室压测量，对照组和生理盐水组的最大声导纳值明显低于正常组和 STS 组（P <.05）。组织病理学检查显示，STS 组的鼓膜比对照组薄（P <.05），钙沉积也比对照组和生理盐水组少。
我们的结果表明，硫代硫酸钠在实验动物模型中对鼓膜硬化的发展具有预防作用。
