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伯氏疏螺旋体基因座连锁的地理差异。

Geographic differences in genetic locus linkages for Borrelia burgdorferi.

机构信息

University of California, Irvine, California 92697-4028, USA.

出版信息

Emerg Infect Dis. 2010 Jul;16(7):1147-50. doi: 10.3201/eid1607.091452.

DOI:10.3201/eid1607.091452
PMID:20587192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3321895/
Abstract

Borrelia burdorferi genotype in the northeastern United States is associated with Lyme borreliosis severity. Analysis of DNA sequences of the outer surface protein C gene and rrs-rrlA intergenic spacer from extracts of Ixodes spp. ticks in 3 US regions showed linkage disequilibrium between the 2 loci within a region but not consistently between regions.

摘要

美国东北部的伯氏疏螺旋体基因型与莱姆病的严重程度有关。对来自美国 3 个地区的硬蜱属 Ixodes spp. 提取物的外表面蛋白 C 基因和 rrs-rrlA 基因间隔区的 DNA 序列进行分析表明，在一个区域内，2 个基因座之间存在连锁不平衡，但在不同区域之间并不一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a55e/3321895/cb7ffcc34686/09-1452-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a55e/3321895/cb7ffcc34686/09-1452-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a55e/3321895/cb7ffcc34686/09-1452-F.jpg

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Am J Trop Med Hyg. 2009 Dec;81(6):1120-31. doi: 10.4269/ajtmh.2009.09-0208.
2
Population structure of the lyme borreliosis spirochete Borrelia burgdorferi in the western black-legged tick (Ixodes pacificus) in Northern California.加利福尼亚北部西部黑腿蜱（Ixodes pacificus）中莱姆病螺旋体伯氏疏螺旋体的种群结构。
Appl Environ Microbiol. 2009 Nov;75(22):7243-52. doi: 10.1128/AEM.01704-09. Epub 2009 Sep 25.
3
Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events.
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mBio. 2024 Sep 11;15(9):e0174924. doi: 10.1128/mbio.01749-24. Epub 2024 Aug 15.
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Possible effect of mutations on serological detection of Borrelia burgdorferi sensu stricto ospC major groups: An in-silico study.可能的突变对伯氏疏螺旋体 ospC 主要组血清学检测的影响：一项计算机模拟研究。
PLoS One. 2023 Oct 10;18(10):e0292741. doi: 10.1371/journal.pone.0292741. eCollection 2023.
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